Screening for Atrial Fibrillation

Table of contents

1. Atrial Fibrillation
2. Screening Studies
   1. STROKESTOP Study
   2. STROKESTOP II Study
   3. SAFER Study
   4. LOOP Study
   5. SCREEN-AF Study
   6. REHEARSE-AF Study
   7. PULsE-AI Trial
3. AF Detection Studies
   1. Apple Heart Study
4. Devices
   1. Zenicor’s handheld ECG device
   2. AliveCor’s Kardia Mobile device
   3. Withings wrist-watch devices
   4. Cardiolund’s ECG Parser algorithm
   5. Context
5. Context
   1. Single-time point screening
   2. ECG-based AF screening
   3. Reviews of screening for AF

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Atrial Fibrillation

• 2020 AF Guidelines: includes the ‘diagnostic criteria for atrial fibrillation’ in Section 3.2.
• Responsible for a fivefold increase in stroke risk

Screening Studies

STROKESTOP Study

Websites:

• Registration

Study Design:

• Publication

Results:

• Screening (before follow-up)
• Follow-up outcomes, and accompanying Comment.
• Geographic and socio-demographic differences in uptake of screening
• Automated ECG analysis algorithm
• Cost-effectiveness

Follow-up study:

• Micro-AF as a risk factor for AF

STROKESTOP II Study

Websites:

• Registration

Study Design:

• Publication

Results:

• Screening (before follow-up)

SAFER Study

Websites:

• Study Website
• SAFER Feasibility Study registration
• SAFER Trial registration

Protocols:

• SAFER Trial Pilot Study

Papers:

• Embedding qualitative research in trials
• Why do people take part in atrial fibrillation screening?

Engineering Analyses:

• Algorithm tags and number of reviewers: initial results
• Prioritising ECGs for manual review

LOOP Study

Results:

• Follow-up outcomes, and accompanying Comment.

SCREEN-AF Study

Websites:

• Registration

Results:

• Screening

REHEARSE-AF Study

Results:

• Screening

PULsE-AI Trial

Results:

• Screening

AF Detection Studies

Apple Heart Study

Study Design:

• Publication

Devices

Zenicor’s handheld ECG device

• Website, including Press images

AliveCor’s Kardia Mobile device

• Website

Withings wrist-watch devices

• Move-ECG
• ScanWatch

Cardiolund’s ECG Parser algorithm

• Website
• Initial Design
• Validation

Context

• Healthcare provider views on devices
• Systematic review and economic evaluation of lead-I ECG devices

Context

Single-time point screening

• Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening

ECG-based AF screening

• Systematic review

Reviews of screening for AF

• Population-based screening for atrial fibrillation - see Table 4 for a list of ongoing studies.
• Screening for atrial fibrillation: A call for evidence
• Screening for atrial fibrillation